A36-year-oldmanpresentedtotheemergencydepartmentwitha2-weekhistoryoffever,headache,drowsiness,andphotophobia.
36岁,男性,发烧、头痛、嗜睡和畏光2周就诊。
Hewaspreviouslyhealthyandwassexuallyactivewithmen.
既往体健,是同性恋。
Thephysicalexaminationwasnotableforatemperatureof38.3°Candneckstiffness.
体格检查:体温38.3℃和颈部僵硬。
Computedtomographyoftheheadwasnormal.
头颅CT正常。
Theopeningpressureonlumbarpuncturewas29cmofwater(referencerange,20cm).
腰椎穿刺的颅内压力为29cm水柱(参考范围,20cm)。
Thecerebrospinalfluid(CSF)cellcountwascellspermicroliter(referencerange,0to10),with90%mononuclearcells,whichwerepredominantlylymphocytes.
脑脊液(CSF)细胞计数为每微升个细胞(参考范围,0至10),其中90%的单核细胞,主要是淋巴细胞。
Theglucoselevelwas46mgperdeciliter(2.6mmolperliter;referencerange,40to70mgperdeciliter[2.2to3.8mmolperliter]),andtheproteinlevelwas0.80gperliter(referencerange,0.15to0.45).
葡萄糖水平为每分升46毫克(每升2.6毫摩尔;参考范围,每分升40-70毫克[2.2-3.8毫摩尔/升]),蛋白质水平为每升0.80克(参考范围,0.15-0.45)。
Gram’sstain(PanelA)andIndiainkstain(PanelB)revealedabundantencapsulated,roundyeasts,withsomebuddingforms.
革兰氏染色(PanelA)和印度墨水染色(PanelB)显示出大量有(胶)囊包着的圆形酵母,以及一些出芽形式。
Thecryptococcalantigentiterwas1:,andtheCSFculturegrewCryptococcusneoformans.
隐球菌抗原效价为1:,脑脊液培养新型隐球菌。
Nootherpathogenwasdetected.
未发现其他病原体。
Atestforthehumanimmunodeficiencyvirusantibodywaspositive;theviralloadwas,copiespermilliliter,andtheCD4+countwas7cellspermicroliter(referencerange,to).
人体免疫缺陷病毒抗体的检测呈阳性;病毒载量为每毫升30万拷贝,CD4+计数为每微升7个细胞(参考范围至)。
InductiontherapywithliposomalamphotericinBandflucytosinewasstarted,andresolutionofsymptomsandnegativeresultsonCSFculturewerenotedafter2weeksoftreatment.
开始用脂质体两性霉素B和氟胞嘧啶进行诱导治疗,治疗2周后,症状得到缓解和脑脊液培养结果阴性。
Consolidationtherapywithfluconazolewasstarted,andantiretroviraltherapywaslaterprescribed.
开始用氟康唑进行巩固治疗,随后抗逆转录病毒治疗。
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